郵箱: zwang01@sinh.ac.cn
電話(huà): +86-21-54920079
所屬部門(mén): 中國(guó)科學(xué)院計(jì)算生物學(xué)重點(diǎn)實(shí)驗(yàn)室
2020-至???今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所 青年研究員
2015-2020年：中國(guó)科學(xué)院上海生命科學(xué)研究院/上海營(yíng)養(yǎng)與健康研究所 副研究員
2012-2015年：中國(guó)科學(xué)院上海生命科學(xué)研究院 博士后
2006-2011年：中國(guó)科學(xué)院上海生命科學(xué)研究院 生物信息學(xué) 博士
2002-2006年：四川大學(xué) 生物科學(xué) 學(xué)士
計(jì)算基因組學(xué)和表型組學(xué)
1. 特殊動(dòng)物表型的遺傳機(jī)制：采用高通量測(cè)序的技術(shù)和分子進(jìn)化的理論，解析動(dòng)物特殊免疫和代謝表型的遺傳基礎(chǔ)。
2. 疾病表型組學(xué)研究：對(duì)疾病動(dòng)物模型和人類(lèi)疾病的表型組進(jìn)行比較分析，為疾病的精準(zhǔn)分型和合理選擇動(dòng)物模型提供依據(jù)。
1.?Wang Z#*, Xie L#, Ding G#, Song S, Chen L, Li G, Xia M, Han D, Zheng Y, Liu J, Xiao T, Zhang H, Huang Y, Li Y*, Huang M*. Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients. Nature Communications. 2021;12(1):5444.
2.?Bai Y, Lin W, Xu J, Song J, Yang D, Chen YE, Li L, Li Y*, Wang Z*, Zhang J*. Improving the genome assembly of rabbits with long-read sequencing. Genomics. 2021;113(5):3216-3223.
3.?Li H#, Wang Z#, Chai S, Bai X, Ding G, Li Y, Li J, Xiao Q, Miao B, Lin W, Feng J, Huang M, Gao C, Li B, Hu W, Lin J, Fu Z*, Xie J*, Li Y*. Genome assembly and transcriptome analysis provide insights into the antischistosome mechanism of Microtus fortis. Journal of Genetics and Genomics 2020;47(12):743-755.
4.?Ming L#, Wang Z#*, Yi L, Batmunkh M, Liu T, Siren D, He J, Juramt N, Jambl T, Li Y, Jirimutu*. Chromosome-level assembly of wild Bactrian camel genome reveals organization of immune gene loci. Molecular Ecology Resources. 2020;20(3):770-780.
5.?Yi L, Dalai M, Su R, Lin W, Erdenedalai M, Luvsantseren B, Chimedtseren C*, Wang Z*, Hasi S*. Whole-genome sequencing of wild Siberian musk deer (Moschus moschiferus) provides insights into its genetic features. BMC Genomics. 2020;21(1):108.
6.?Ming L, Yuan L, Yi L, …, Li Y*, Wang Z*, Jirimutu*. Whole-genome sequencing of 128 camels across Asia reveals origin and migration of domestic Bactrian camels. Communications Biology. 2020;3(1):1.
7.?Miao B, Xiao Q, Chen W, Li Y*, Wang Z*. Evaluation of functionality for serine and threonine phosphorylation with different evolutionary ages in human and mouse. BMC Genomics. 2018;19(1):431.
8.?Zhou L, Xiao Q, Bi J, Wang Z*, Li Y*. RabGTD: a comprehensive database of rabbit genome and transcriptome. Database. 2018;2018:bay075.
9.?Chen W, Li Y*, Wang Z*. Evolution of oncogenic signatures of mutation hotspots in tyrosine kinases supports the atavistic hypothesis of cancer. Scientific Reports. 2018;8(1):8256.
10.?Miao B, Wang Z*, Li Y*. Genomic Analysis Reveals Hypoxia Adaptation in the Tibetan Mastiff by Introgression of the Grey Wolf from the Tibetan Plateau. Molecular Biology and Evolution. 2017;34(3):734-743. Highlighted by Science News, Christian Science Monitor and Smithsonian Magazine.
11.?Wang Z#, Zhang J#, Li H#, Li J, et al. Hyperlipidemia-associated gene variations and expression patterns revealed by whole-genome and transcriptome sequencing of rabbit models. Scientific Reports. 2016;6:26942.
12.?Xiao Q, Miao B, Bi J, Wang Z*, Li Y*. Prioritizing functional phosphorylation sites based on multiple feature integration. Scientific Reports. 2016;6:24735.
13.?Gou X#, Wang Z#, Li N#, Qiu F#, et al. Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia. Genome Research. 2014;24(8):1308-1315.
14.?Jirimutu#, Wang Z#, Ding G#, Chen G#, Sun Y#, et al. Genome sequences of wild and domestic bactrian camels. Nature Communications. 2012;3:1202. Highlighted by Nature News.
Niu S#, Wang Z#, Ge D, Zhang G, Li Y. Prediction of functional phosphorylation sites by incorporating evolutionary information. Protein & Cell. 2012;3(9):675-690.
15.?Wang Z#, Ding G#, Geistlinger L, Li H, Liu L, Zeng R, Tateno Y, Li Y. Evolution of protein phosphorylation for distinct functional modules in vertebrate genomes. Molecular Biology and Evolution. 2011;28(3):1131-1140.
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