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大數(shù)據(jù)水平的基因表達(dá)調(diào)控的整合性規(guī)律團(tuán)隊(duì)

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靳文菲

博士

多組學(xué)與腫瘤研究組組長(zhǎng)

郵箱: jinwf@sinh.ac.cn

電話: +86-21-54920532

研究組主頁: https://sinh-jinlab.github.io/

所屬部門: 中國(guó)科學(xué)院計(jì)算生物學(xué)重點(diǎn)實(shí)驗(yàn)室

個(gè)人簡(jiǎn)歷

2023–至???今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所，研究員
2017-2023年：南方科技大學(xué)，副教授，研究員
2013-2017年：美國(guó)國(guó)立衛(wèi)生研究院(NIH)，博士后
2012-2012年：中國(guó)科學(xué)院-馬普學(xué)會(huì)計(jì)算生物學(xué)伙伴研究所，助理研究員
2006-2012年：中國(guó)科學(xué)院-馬普學(xué)會(huì)計(jì)算生物學(xué)伙伴研究所，計(jì)算生物學(xué)，博士
2001-2006年：鄭州大學(xué)，生物技術(shù)，學(xué)士

研究方向

組學(xué)，生物信息，腫瘤免疫

研究?jī)?nèi)容

　　研究組致力于開發(fā)和整合組學(xué)技術(shù)和生物信息手段提升精準(zhǔn)醫(yī)學(xué)。即基于多種組學(xué)技術(shù)刻畫人的衰老和癌癥樣本，通過建立新的人工智能算法和模型解析生物學(xué)過程，鑒定關(guān)鍵信號(hào)和分子靶點(diǎn)。主要研究方向：
　　（1）開發(fā)組學(xué)技術(shù)和組學(xué)計(jì)算方法，尤其是單細(xì)胞多組學(xué)技術(shù)及其分析方法；
　?。?）多組學(xué)數(shù)據(jù)整合，構(gòu)建全息細(xì)胞圖譜解析細(xì)胞解析細(xì)胞對(duì)外界刺激的應(yīng)答；
　　（3）利用單細(xì)胞技術(shù)解析腫瘤微環(huán)境和腫瘤微進(jìn)化，發(fā)展精準(zhǔn)免疫治療。

代表論著（#第一作者，*通訊作者）

Huang C#, Wang X#, Wang Y#, Feng Y, Wang X, Chen S, Yan P, Liao J, Zhang Q, Mao C, Li Y, Wang L, Wang X, Yi W, Cai W, Chen S, Hong N*, He W*, Chen J*, Jin W* (2023) Sirpα on tumor-associated myeloid cells restrains anti-tumor immunity in colorectal cancer independent of its interaction with CD47. Nat Cancer (In Press)
Yi H#*, Lin Y#, Chang Q, Jin W* (2023) A fast and globally optimal solution for RNA-seq quantification. Brief Bioinform Aug 18;bbad298. (Advanced online)
Li H#, Liu H#, Liu Y#, Wang X, Yu S, Huang H, Shen X, Zhang Q, Hong N, Jin W* (2023) Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq. iScience Aug 9;26(9):107588.
Zhou J#, Chen G#, Wang J#, Zhou B, Sun X, Wang J, Tang S, Xing X, Hu X, Zhao Y, Peng Y, Shi W, Zhao T, Wu Y, Zhong H, Hong N, Ruan Z*, Zhang Y*, Jin W* (2023) Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer. Oncogenesis Apr 20;12(1):22.
Wang J#, Chen W#, Yue W, Hou W, Rao F, Zhong H, Qi Y*, Hong N*, Ni T*, Jin W* (2022) Comprehensive mapping of alternative polyadenylation site usage and its dynamics at single cell resolution. Proc Natl Acad Sci U S A Dec 6;119(49):e2113504119.
Xu W#,Yang W#, Zhang Y, Chen Y, Hong N, Zhang Q, Wang X, Hu Y, Song K, Jin W*, Chen X* (2022) ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells. Nat Methods Oct;19(10):1243-1249.
Wang X#, Shen X#, Chen S, Liu H, Hong N, Zhong H, Chen X, Jin W* (2022) Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing. J Immunol Jan 15;208(2):396-406.
Yi G, Lin Y, Lin C, Jin W* (2021) Kssd: sequence dimensionality reduction by k-mer substring space sampling enables real-time large-scale datasets analysis. Genome Biol Mar 16;22(1):84.
Qin P#, Pang Y#, Hou W#, Fu R#, Zhang Y#, Wang X#, Meng G, Liu Q, Zhu X, Hong N*, Cheng T*, Jin W* (2021) Integrated decoding hematopoiesis and leukemogenesis using single cell sequencing and its medical implication. Cell Discov Jan 5;7(1):2.
Han Z, Cui K, Placek K, Hong N, Lin C, Chen W, Zhao K*, Jin W* (2020) Diploid genome architecture revealed by multi-omic data of hybrid mice. Genome Res Aug;30(8):1097-1106.
Lai B#, Tang Q#, Jin W#, Hu G#, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K (2018) Trac-looping measures genome structure and chromatin accessibility. Nat Methods Sep;15(9):741-747.
Ren G#, Jin W#, Cui K, Rodrigez J, Hu G, Zhang Z, Larson DR, Zhao K (2017) CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression. Mol Cell Sep 21;67(6):1049-1058.
Jin W#, Tang Q#, Wan M, Cui K, Zhang Y, Ren G, Ni B, Sklar J, Przytycka T, Childs R, Levens D, Zhao K (2015) Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples. Nature Dec 3;528(7580):142-146.
Jin W#, Li R#, Zhou Y, Xu S (2014) Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping. Euro J Hum Genet Jul;22(7):930-937.
Kraushaar DC#, Jin W#, Maunakea A, Abraham B, Ha M, Zhao K (2013) Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol 14(10):R121.
Jin W, Wang S, Wang H, Jin L, Xu S (2012) Exploring population admixture dynamics via empirical and simulated genome-wide distribution of ancestral chromosomal segments. Am J Hum Genet Nov 2;91(5):849-862.
Jin W, Qin P, Lou H, Jin L, Xu S (2012) A systematic characterization of genes underlying both complex and Mendelian diseases. Hum Mol Genet Apr 1;21(7):1611-1624.
Jin W, Xu S, Wang H, Yu Y, Shen Y, Wu B, Jin L (2012) Genome-wide detection of natural selection in African Americans pre- and post-admixture. Genome Res Mar;22(3):519-527.

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研究團(tuán)隊(duì)

靳文菲

個(gè)人簡(jiǎn)歷

研究方向

研究?jī)?nèi)容

代表論著（#第一作者，*通訊作者）

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代表論著（#第一作者，*通訊作者）